Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.9
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12[as Cyanocobalamin, Methylcobalamin (Co-enzyme Form)and Dibencozide (Co-enzyme Form)]
2 mg (2,000 mcg)
83,333%
Top Medical Research Studies
0
Vitamin B12 ineffective for CFS
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
Read More
8
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Read More
8
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
Read More
Most Useful Reviews
7.5
Fatigue alleviated
205 people found this helpful
After a week, the constant drowsiness faded, and I felt a renewed desire for vigorous activity. The persistent fatigue and headaches have disappeared.
Read More
7.5
Fatigue eliminated
2 people found this helpful
After a month of taking these vitamin B12 + Folic Acid tablets, the constant drowsiness and fatigue disappeared, and my headaches also ceased.
Read More
9
Daily energy boost
As a diabetic and heart patient, I often deal with chronic fatigue syndrome. I truly believe that taking this small pill helps me get through the day.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
- All Researches
8
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Read More
8
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
Read More
8
We recently came across an intriguing study that highlighted the potential benefits of a combination therapy involving lofepramine, L-phenylalanine, and vitamin B12 for patients suffering from multiple sclerosis (MS). Conducted as a randomized, placebo-controlled double-blind trial, the research aimed to evaluate how this combination could help alleviate various symptoms associated with MS and chronic pain.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
Read More
7
Vitamin B12 shows unclear benefits
We explored the effect of vitamin B12 on individuals diagnosed with chronic fatigue syndrome. The study focused on assessing how this vitamin might alleviate the symptoms associated with the condition. While many participants underwent concurrent treatments, which complicates isolating vitamin B12's specific impact, the research still provides insightful data.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
Read More
7
We observed that a group of twelve outpatients, all women diagnosed with both fibromyalgia and chronic fatigue syndrome, participated in a study focused on understanding the role of vitamin B12 in their condition. While most of their blood lab results were normal, one significant finding stood out: all patients had elevated levels of homocysteine in their cerebrospinal fluid.
The study found a noteworthy link between these increased homocysteine levels and the degree of fatigue experienced by the patients. Moreover, low levels of vitamin B12 in the cerebrospinal fluid were correlated with feelings of fatigue, suggesting that vitamin B12 might play a vital role in how these patients feel day-to-day.
The researchers concluded that the elevation of homocysteine in the central nervous system could be indicative of fibromyalgia and chronic fatigue syndrome. They suggested that a deficiency in vitamin B12 might hinder the body's ability to regulate homocysteine, contributing to the symptoms of fatigue these patients experience. However, while vitamin B12 is shown to be important in this context, the study does not specifically isolate its effects from other contributing factors or treatments.
The study found a noteworthy link between these increased homocysteine levels and the degree of fatigue experienced by the patients. Moreover, low levels of vitamin B12 in the cerebrospinal fluid were correlated with feelings of fatigue, suggesting that vitamin B12 might play a vital role in how these patients feel day-to-day.
The researchers concluded that the elevation of homocysteine in the central nervous system could be indicative of fibromyalgia and chronic fatigue syndrome. They suggested that a deficiency in vitamin B12 might hinder the body's ability to regulate homocysteine, contributing to the symptoms of fatigue these patients experience. However, while vitamin B12 is shown to be important in this context, the study does not specifically isolate its effects from other contributing factors or treatments.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Fatigue alleviated
205 people found this helpful
After a week, the constant drowsiness faded, and I felt a renewed desire for vigorous activity. The persistent fatigue and headaches have disappeared.
Read More
7.5
Fatigue eliminated
2 people found this helpful
After a month of taking these vitamin B12 + Folic Acid tablets, the constant drowsiness and fatigue disappeared, and my headaches also ceased.
Read More
9
Daily energy boost
As a diabetic and heart patient, I often deal with chronic fatigue syndrome. I truly believe that taking this small pill helps me get through the day.
Read More
7.5
Mental clarity improved
22 people found this helpful
This is perfect for vegans and children! I bought it for my vegan teenager, who needed vitamin B12. With a weekly dosage of 2000 mcg, it helps alleviate fatigue and improve memory without side effects if taken moderately.
Read More
7.5
Nutritional benefits noted
4 people found this helpful
After suspecting a B12 deficiency due to chronic gastritis, I began this supplement. It helped cure angular cheilitis and improve my overall health, including my blood condition.
Read More
Frequently Asked Questions
7.5
Fatigue alleviated
205 people found this helpful
After a week, the constant drowsiness faded, and I felt a renewed desire for vigorous activity. The persistent fatigue and headaches have disappeared.
7.5
Fatigue eliminated
2 people found this helpful
After a month of taking these vitamin B12 + Folic Acid tablets, the constant drowsiness and fatigue disappeared, and my headaches also ceased.
9
Boosted energy levels
Very good! I've been taking the Vitamin B12 supplement for a few weeks and experienced a notable boost in my energy levels and mental clarity. The small, easy-to-swallow tablets are convenient, and there’s no unpleasant aftertaste. Overall, it’s a great addition to my routine, particularly for managing chronic fatigue syndrome. Highly recommend!
7.5
Mental clarity
This is great for tackling fatigue and mental 'fogginess' associated with gastrointestinal disorders and chronic fatigue syndrome. The lozenges work better than regular tablets for effective delivery. Low-priced, which is a bonus.
7.5
Energy boost achieved
2 people found this helpful
I am impressed with the quality of this supplement. The small, sublingual tablets taste pleasant and, when combined with methylfolate, have effectively improved my memory, nervous system, and overall energy levels.
7.5
Reduced fatigue
I bought this to help relieve fatigue and nerve pain. The pink tablets have a strawberry flavour, and I feel they have helped reduce my fatigue and stiff shoulders. I plan to use it for a long time, especially for my chronic fatigue syndrome.
7.5
Resourceful energy
These tasty lollipops help combat fatigue and keep me feeling energised throughout the day.
7.5
Mental clarity improved
22 people found this helpful
This is perfect for vegans and children! I bought it for my vegan teenager, who needed vitamin B12. With a weekly dosage of 2000 mcg, it helps alleviate fatigue and improve memory without side effects if taken moderately.
7.5
Chronic fatigue help
Seems to be working as an easy and affordable solution for my chronic fatigue syndrome. The strength specified by my MD enhances my confidence in this product.
8
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
8
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
7
Vitamin B12 shows unclear benefits
We explored the effect of vitamin B12 on individuals diagnosed with chronic fatigue syndrome. The study focused on assessing how this vitamin might alleviate the symptoms associated with the condition. While many participants underwent concurrent treatments, which complicates isolating vitamin B12's specific impact, the research still provides insightful data.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
7
Vitamin B12 shows unclear benefits
We explored the effect of vitamin B12 on individuals diagnosed with chronic fatigue syndrome. The study focused on assessing how this vitamin might alleviate the symptoms associated with the condition. While many participants underwent concurrent treatments, which complicates isolating vitamin B12's specific impact, the research still provides insightful data.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
References
- van Campen CLM, Riepma K, Visser FC. Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders. Front Pharmacol. 2019;10:1102. 10.3389/fphar.2019.01102
- Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. 10.1371/journal.pone.0124648
- Loder C, Allawi J, Horrobin DF. Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems. Med Hypotheses. 2002;59:594.
- Devitt NF. Chronic fatigue syndrome. JAMA. 1998;279:432.
- Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, et al. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol. 1997;26:301.
- Wiebe E. N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports. Can Fam Physician. 1996;42:2214.
- Demitrack MA, Engleberg NC. Chronic fatigue syndrome. Curr Ther Endocrinol Metab. 1994;5:135.
